Maladaptive Proximal Tubule Repair: Cell Cycle Arrest
نویسندگان
چکیده
منابع مشابه
Maladaptive proximal tubule repair: cell cycle arrest.
Acute kidney injury (AKI) leads to worsening of chronic kidney disease (CKD), and CKD predisposes to the clinical entity of AKI. The tubules of the kidney play a central role in the fibrotic response, which ultimately leads to progressive kidney disease. The cellular mechanisms responsible for the epidemiological association between AKI and CKD are complex. In order to unravel characteristics o...
متن کاملMaladaptive Proximal Tubule Repair: Cell Cycle Arrest
Acute kidney injury (AKI) leads to worsening of chronic kidney disease (CKD), and CKD predisposes to the clinical entity of AKI. The tubules of the kidney play a central role in the fibrotic response, which ultimately leads to progressive kidney disease. The cellular mechanisms responsible for the epidemiological association between AKI and CKD are complex. In order to unravel characteristics o...
متن کاملPrimary proximal tubule injury leads to epithelial cell cycle arrest, fibrosis, vascular rarefaction, and glomerulosclerosis
Tubular injury has a major etiological role in fibrosis. For many years, this relationship has been dominated by the perception that epithelial cells are transformed into myofibroblasts that proliferate and generate fibrotic matrix-the so-called epithelial-to-mesenchymal transition. Here we focus on mechanisms by which injury to the tubule results in fibrosis because of paracrine mechanisms. Sp...
متن کاملNebivolol attenuates maladaptive proximal tubule remodeling in transgenic rats.
BACKGROUND/AIMS The impact of nebivolol therapy on the renal proximal tubular cell (PTC) structure and function was investigated in a transgenic (TG) rodent model of hypertension and the cardiometabolic syndrome. The TG Ren2 rat develops nephropathy with proteinuria, increased renal angiotensin II levels and oxidative stress, and PTC remodeling. Nebivolol, a beta(1)-antagonist, has recently bee...
متن کاملThe Proximal Tubule Cell in Experimental Hydronephrosis
The purpose of this report is to record several observations made in a study of hydronephrosis produced in rats by unilateral ligation of the ureter. I t has been known from the work of Wilmer (1) and Wachstein (2, 3) that the staining of the proximal tubule brush border for alkaline phosphatase activity is diminished in experimental hydronephrosis. However, the speed with which this decrease o...
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ژورنال
عنوان ژورنال: Nephron Clinical Practice
سال: 2014
ISSN: 1660-2110
DOI: 10.1159/000363673